Abstract
Alzheimer's disease (AD) accounts for a significant proportion of long-term care costs. The recent discovery that the e4 allele of the ApoE gene indicates a predisposition to earlier onset of AD raises questions about the potential for adverse selection in long-term care insurance, about long-term care costs in general, and about the potential effects on costs of gene therapy, or better targeted treatments for AD. This paper describes a simple Markov model for AD, and the estimation of the transition intensities from the medical and epidemiological literature.
Keywords: Alzheimer's Disease, Apolipoprotein E Gene, Genetics, Markov Models.
Volume
30:1
Page
69-110
Year
2000
Categories
Actuarial Applications and Methodologies
Ratemaking
Classification Plans
Financial and Statistical Methods
Aggregation Methods
Collective Risk Model
Financial and Statistical Methods
Loss Distributions
Frequency
Business Areas
Other Lines of Business
Financial and Statistical Methods
Statistical Models and Methods
Publications
ASTIN Bulletin
